It's Destruction, Hob Gadling and Dream from Gaiman's Sandman comic.

Gadling is a human from the 14th century, who said and believed, "Death's a mug's game..." "...The only reason people die, is because everyone does it. You all just go along with it. It's rubbish, death. It's stupid. I don't want to have anything to do with it."

This little speech was heard by Dream and his sister, Death, who got interested and decided that she won't be taking him unless he wants her to. Dream found this amusing, too, so he took the liberty to tell ole Hob of his good news. They agreed to meet each other at the same place every hundred years.

So, once every hundred years, Hob Gadling met up with Dream. Hob had been a knighted shipyard owner, a slaver, a beggar. The two became very attached to each other: Hob because Dream is the only person he knew since the 14th century; Dream because Hob is the only person who ever connects with him on a personal level, the fact Hob confronted him with in the 19th century, the fact that Dream angrily denied then.

But in the 20th, Dream came to Hob at the same tavern - now, a cafe.

Their friendship is one of the best I've read in fiction. And this panel always touches me, whenever I see it.